[Dock-fans] Dealing with very large receptors

Francesco Pietra chiendarret at gmail.com
Thu Jan 13 13:24:40 PST 2011


Hello:
When forced to carry out blind docking in the absence of any ad hoc
information, while the protein is too large to work with a grid (at
least at 0.3 resolution), which chances are left to proceed soundly?

(1) Abandon the case, no hope.

(2) Use a larger grid resolution. How much large could it be?

(3) Docking without using a grid.

(3) Do at grid 0.3 resolution but select portions of the protein, one
each time. This one I tried. No reliable results.

Thanks for comments

francesco pietra


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