[Dock-fans] TZD Tautomer Distribution

Nancy nancy5villa at gmail.com
Mon Jan 17 11:26:16 PST 2011


Hi All,

For pioglitazone, are the two tautomers depicted in the attached figure the
major forms at pH 7.0?

Also, are there any published articles, or other evidence that would confirm
that this is indeed the correct tautomeric distribution at pH 7?

Thank you,
Nancy
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