[Zinc-fans] SEA predictions

John J. Irwin jji at cgl.ucsf.edu
Mon May 4 13:39:32 PDT 2009


Sorry, made a typo, change "out" to "one". 

>> 2. What does pPvalue:10 mean?
> The p is as in -log10, so the P-value is 10^-10.  This can be read as
> "you would expect to draw 10^10 molecules at random to find ONE that
> was as similar to the annotated compounds as this one is".  Our cutoff
> for "interesting" SEA predictions is often 10^-10.  Whereas this does
> not guarantee the ligand will be active, it is worth looking at.
>
>   


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